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ACS |
| Overview |
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Plaques |
| Properties |
| Role of acute changes |
| Erosion & Disruption |
| Types |
| Fissuring & Rupture |
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MI |
| Different forms of MI |
| Q Wave MI |
| Non-Q MI & Unstable Angina |
| Treatment of ACS |
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Role of Acute Plaque Changes ¡@ |
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Slowly accruing high grade stenosis may progress to total occlusion without MI because of collaterals development ¡@ |
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Abrupt plaque rupture causes mechanical obstruction and exposure of substances that promote platelet activation and thrombus generation , thereby decreasing blood flow which, if persistent, causes Myocardial Necrosis. | |
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The Basic Process in Atherosclerosis. ¡@ Plasma low-density lipoprotein (LDL), which has entered the intima, become modified and induces changes in the endothelium leading to monocyte migration. Within the intima further oxidation of LDL leads to form that is actively taken up by macrophages to form foam cells. Macrophage death releases lipid to form the core. Growth factors released by endothelial cells and macrophages stimulate smooth muscle growth and connective tissue matrix synthesis. |
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Notes |
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